A man’s body was discovered by the side of a road near the southern town of Dimona on Saturday morning.
According to the Kan public broadcaster, the man in his 40s had a stab wound to his torso.
Medics on the scene declared his death.
Police said they have opened an investigation into the circumstances surrounding the incident.
According to the Ynet news site, a knife was found close to the man’s body at the side of Route 25, one of the main arteries in the south of the country.
The report said a vehicle at the scene still had its engine running when emergency services arrived, and that there was luggage in the car. Police were looking into the possibility the man was en route to a vacation, Ynet said.
The body was reportedly found around 50 meters (approximately 164 feet) from the vehicle.