New Delhi: The Union Health Ministry on Wednesday said that around 40 cases of the Delta Plus variant classified as a type of concern (VOC) have been found sporadically in Maharashtra, Kerala and Madhya Pradesh. All Delta sub-lineages, including the Delta variant as well as the Delta Plus, are classified as VOCs, it said.
“So far in samples sequenced in India (45000+), the Delta Plus variant – AY.1 – has been observed sporadically in Maharashtra, Kerala and Madhya Pradesh, with around 40 cases identified so far and no increase in prevalence. There has not been a significant increase,” the ministry said in its statement.
These three states have been advised to strengthen surveillance and take appropriate public health measures.
Following the report of AY.1 by Public Health England (PHE) on 11 June, a retrospective analysis of samples revealed the first occurrence of this lineage from a sample collected from Maharashtra. The sample was collected on April 5. As of June 18, 205 sequences of the AY.1 lineage had been detected worldwide, with more than half the known cases in the United States and the UK, the statement said.
INSACOG recently identified a viral variant (Delta, B.1.617.2). This viral variant has also been seen in nine other countries of the world. INSACOG is an Indian consortium of 28 laboratories, set up by the Government of India to conduct genome sequencing of the virus causing the COVID-19 pandemic.
The World Health Organization has introduced a classification as VOC (type of concern) and VOI (type of interest), with several forms developing around the world. The Delta variant as well as all Delta sub-lineages, including the Delta Plus, are classified as VOCs, the statement said.
The Indian SARS-CoV-2 Genomic Consortia (INSACOG) reported the evolution of a delta plus variant (B.1.617.2) + K417N lineage of SARS-CoV2, termed B.1.617.2.1/AY.1.
The delta plus variant B.1.617.2.1/ (AY.1) is characterized by a K417N mutation in the spike protein, the statement said. The spike protein assists the virus to gain receptor-mediated entry into human cells. The K417N spike corresponds to a change in the amino acid lysine (K) to asparagine (N) at position 417 of the protein. There are other Delta Plus versions with other mutations. AY.1 is the most famous, but they are not the same. A second clade found in sequences uploaded to GISAID from the United States is now named AY.2, but has not yet been observed in India, the statement said.
“All delta sub-lineages are treated as a variant of the concern VOC, although the properties of AY.1 are still being investigated. At present, the variant frequency of AY.1 in India is low. AY. Cases of 1 have been reported mostly from nine countries in Europe, Asia and the Americas,” the ministry statement said.
The COVID-19 disease caused by the SARS-CoV-2 virus continues to mutate with an increase in the number of infections both around the world and in India. Mutations help the virus to become either more transmissible or more virulent, or both. Over time these mutations, known as variants of interest (VOIs), increase in frequency in the selected population and are then considered VOCs.
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